CD4+ T-cell responses to herpes simplex virus type 2 (HSV-2) glycoprotein G are type specific and differ in symptomatic and asymptomatic HSV-2-infected individuals
نویسندگان
چکیده
منابع مشابه
Seroepidemiological Study of Herpes Simplex Virus Type 2 (HSV-2) Antibody in Shiraz, Iran
Background: Herpes Simplex Virus (HSV) Type 2 is a widespread human infectious agent responsible for persistent and latent infections. Objectives: To estimate the regional seroprevalence of anti HSV-2 antibody in Shiraz, Iran and to investigate the possible correlation of seropositivity with malignant changes in subjects’ Papanicolaou (Pap) tests. Methods: Data were collected in a cross-section...
متن کاملAsymptomatic herpes simplex virus type 2 (HSV-2) infection among pregnant women in Turkey.
BACKGROUND & OBJECTIVES A large proportion of individuals with serologic evidence of infection with herpes simplex virus type 2 (HSV-2) are asymptomatic. HSV-2 is the main cause of genital herpes infections. The acquisition of genital herpes during pregnancy has been associated with spontaneous abortion, premature labour and congenital and neonatal herpes. The present study was undertaken to de...
متن کاملNo Role of Herpes Simplex Virus Type 2 (HSV-2) Infection on HIV Progression in Naïve HIV Patients
Background: Herpes simplex virus type 2 (HSV-2) is a common infection in human immunodeficiency virus (HIV) patients and may accelerate HIV progression by rising HIV viral load and decreasing CD4 count. However, the available data regarding the influence of HSV-2 seropositivity on HIV progression in HIV individuals are inconclusive. Therefore, we aimed to determine HSV-2 seroprevalence in na&iu...
متن کاملImmunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects.
In human recurrent cutaneous herpes simplex, there is a sequential infiltrate of CD4 and then CD8 lymphocytes into lesions. CD4 lymphocytes are the major producers of the key cytokine IFN-gamma in lesions. They recognize mainly structural proteins and especially glycoproteins D and B (gD and gB) when restimulated in vitro. Recent human vaccine trials using recombinant gD showed partial protecti...
متن کاملseroepidemiological study of herpes simplex virus type 2 (hsv-2) antibody in shiraz, iran
background: herpes simplex virus (hsv) type 2 is a widespread human infectious agent responsible for persistent and latent infections. objectives: to estimate the regional seroprevalence of anti hsv-2 antibody in shiraz, iran and to investigate the possible correlation of seropositivity with malignant changes in subjects’ papanicolaou (pap) tests. methods: data were collected in a cross-section...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2004
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.79978-0